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Compound category: Pyrimidines and pyrimidine derivatives
(total 20 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
ML346 Depiction based on curated SMILES O HN O N H O CH 3 O Streptococcus Adherence Preclinical (in vivo) Guan XN, et al. 2022. RSC Med Chem
5-Fluorouracil Depiction based on curated SMILES O HN O N H F Staphylococcus
Vibrio		 Biofilm
Biofilm		 Preclinical (in vivo)
Preclinical (in vivo)		 Sedlmayer F, et al. 2021. Nucleic Acids Res
Fursultiamin Depiction based on curated SMILES N NH 2 O S S OH CH 3 CH 3 O N N Vibrio HlyU Preclinical (in vivo) Imdad S, et al. 2018. Front Cell Infect Microbiol
4,6-dimethyl-N-[(Z)-1-pyridin-2-ylethylideneamino]pyrimidin-2-amine Depiction based on curated SMILES CH 3 N CH 3 CH 3 N HN N N Brucella VirB type IV secretion system Preclinical (in vivo) Paschos A, et al. 2011. Infect Immun
2-(4-tert-Butyl-phenoxymethyl)-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester Depiction based on curated SMILES CH 3 H 3 C H 3 C O CH 3 O HN N O O Brucella VirB type IV secretion system Preclinical (in vivo) Paschos A, et al. 2011. Infect Immun
(5E)-5-({4-[(2,4-DICHLOROPHENYL)METHOXY]-3-ETHOXYPHENYL}METHYLIDENE)-1-(3,5-DIMETHYLPHENYL)-1,3-DIAZINANE-2,4,6-TRIONE Depiction based on curated SMILES H 3 C CH 3 O O Cl Cl O CH 3 O NH O N Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
(5E)-5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-1-(3,5-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione Depiction based on curated SMILES CH 3 O N H O Cl Cl O CH 3 O N Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
5-{3-[(2,4-difluorophenoxy)methyl]-4-methoxybenzylidene}-2,4,6(1H,3H,5H)-pyrimidinetrione Depiction based on curated SMILES O F F O O N H CH 3 HN O O Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
5-{4-[(2,4-dichlorobenzyl)oxy]-3-ethoxybenzylidene}pyrimidine-2,4,6(1H,3H,5H)-trione Depiction based on curated SMILES Cl Cl O O NH O H 3 C HN O O Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
2-(3-Pyridinyl)-3-(4-methoxyphenyl)-3,4-dihydroquinazoline-4-one Depiction based on curated SMILES N O CH 3 N N O Klebsiella Aerobactin Preclinical (in vitro) Bailey DC, et al. 2018. SLAS Discov
   


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