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Fursultiamin

Drug details:
Molecular formula: C17H26N4O3S2

Classification: Pyrimidines and pyrimidine derivatives; Diazines; Organoheterocyclic compounds; Organic compounds;
Synonyms:  Alinamin F
Thiamine tetrahydrofurfuryl disulfide
Thiamin tetrahydrofurfuryl disulfide
Diteftin
Alinamin-f
Aliaron F
Judolor
fursultiamine hydrochloride
Linamin
......

Chemical structure:
Depiction based on curated SMILES N NH 2 O S S OH CH 3 CH 3 O N N

Evidence for compound's anti-virulence activity:

Vibrio
Related VF: HlyU
Target: HlyU
Drug effect: Inhibits the transcription of the highly invasive repeat-in-toxin (rtxA1) and hemolysin (vvhA) along with other HlyU regulated virulence genes.
Max phase: Preclinical (in vivo)
Publication:
Imdad S, et al., 2018. Identification and Validation of an Antivirulence Agent Targeting HlyU-Regulated Virulence in Vibrio vulnificus. Front Cell Infect Microbiol 8:152.








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