Drug details:
Molecular formula: C₁₄H₁₂N₂O₄

Standard name: 5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione

Synonyms:

(E)-5-(3-(4-methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 5-[(2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]pyrimidine-2,4,6(1H,3H,5H)-trione 5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione 5-[(2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-1,3-diazinane-2,4,6-trione 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1h,3h,5h)-pyrimidinetrione 5-[3-(4-Methoxyphenyl)-2-propenylidene]pyrimidine-2,4,6(1H,3H,5H)-trione

Curated SMILES: COC1=CC=C(/C=C/C=C2C(=O)NC(=O)NC2=O)C=C1

Evidence for compound's anti-virulence activity:

Streptococcus
Related VFcategory: Adherence
Target: SrtA
Drug effect: Covalent inhibitor of SrtA, a membrane-associated cysteine transpeptidase essential for anchoring some surface adhesins.
Max phase: Preclinical (in vivo)
Publication:
Guan XN, et al., 2022. Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella. RSC Med Chem 13(2):138-149.