Drug details:
Molecular formula: C₁₈H₂₂N₂O₄

Standard name: ethyl 2-[(4-tert-butylphenoxy)methyl]-6-oxo-1H-pyrimidine-5-carboxylate

Synonyms:

Ethyl 2-[(4-tert-butylphenoxy)methyl]-4-hydroxy-5-pyrimidinecarboxylate # Ethyl 2-[[4-(1,1-dimethylethyl)phenoxy]methyl]-1,6-dihydro-6-oxo-5-pyrimidinecarboxylate

Curated SMILES: CCOC(=O)C1=CN=C(NC1=O)COC2=CC=C(C=C2)C(C)(C)C

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.