Drug details:
Classification: Naphthalenes; Benzenoids; Organic compounds;

Curated SMILES: CCCCCC1=CC=CC2=C1C(/C=C/C(=O)O)=CC=C2

Evidence for compound's anti-virulence activity:

Vibrio
Related VF: TCP (Toxin-coregulated pilus)
Target: TcpN/ToxT
Drug effect: Inhibits ToxT, an AraC family regulator that binds the tcpA and ctx promoters and directly activates virulence gene expression.
Max phase: Preclinical (in vitro)
Publication:
Woodbrey AK, et al., 2018. A Modified ToxT Inhibitor Reduces Vibrio cholerae Virulence in Vivo. Biochemistry 57(38):5609-5615.