Drug details:
Molecular formula: C₂₉H₂₆ClFN₄O₄S

Standard name: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

Synonyms:

Lapatinib Ditosylate Tykerb Lapatinib [INN] Lapatinib base Tyverb Lapatinib tosilate hydrate Lapatinib (INN) Lapatinib free base N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine ......

Curated SMILES: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Evidence for compound's anti-virulence activity:

Streptococcus
Related VFcategory: Adherence
Target: BspC
Drug effect: Targets the vimentin-binding pocket of BspC to block GBS adherence and entry into the brain.
Max phase: Preclinical (in vivo)
Publication:
Manzer HS, et al., 2022. Targeting the BspC-vimentin interaction to develop anti-virulence therapies during Group B streptococcal meningitis. PLoS Pathog 18(3):e1010397.