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(E)-N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)-3-[3-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]prop-2-enamide

Drug details:
Molecular formula: C22H19N3O4S3

Classification: Hydroxycinnamic acids and derivatives; Cinnamic acids and derivatives; Phenylpropanoids and polyketides; Organic compounds;
Chemical structure:
Depiction based on curated SMILES S S O O CH 3 S H 3 C N HN O O N

Evidence for compound's anti-virulence activity:

Shigella
Related VF: TTSS (Type III secretion system)
Target: Spa47
Drug effect: Inhibits T3SS ATPase.
Max phase: Preclinical (in vitro)
Publication:
Case HB, et al., 2018. Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors. Biochemistry 57(50):6906-6916.








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