Drug details:
Molecular formula: C₂₁H₂₄N₆O₂S

Standard name: 6-[4-(2,4-dimethylphenyl)sulfonylpiperazin-1-yl]-N-pyridin-4-ylpyridazin-3-amine

Curated SMILES: CC1=CC(C)=C(S(=O)(=O)N2CCN(C3=CC=C(NC4=CC=NC=C4)N=N3)CC2)C=C1

Evidence for compound's anti-virulence activity:

Shigella
Related VF: TTSS (Type III secretion system)
Target: Spa47; IpaC
Drug effect: Inhibits transcriptional activator.
Max phase: Preclinical (in vivo)
Publication:
Case HB, et al., 2020. Novel Noncompetitive Type Three Secretion System ATPase Inhibitors Shut Down Shigella Effector Secretion. Biochemistry 59(28):2667-2678.