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Compound category: Piperazines
(total 17 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
4-methyl-2-(4-methylphenyl)-6-{5-[(4-phenylpiperazin-1-yl)carbonyl]-1,2,4-oxadiazol-3-yl}-1,2,4-triazine-3,5(2H,4H)-dione Depiction based on curated SMILES N N O N CH 3 O N N N CH 3 O O N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
4-methyl-2-phenyl-6-{5-[(4-phenylpiperazin-1-yl)carbonyl]-1,2,4-oxadiazol-3-yl}-1,2,4-triazine-3,5(2H,4H)-dione Depiction based on curated SMILES N N N O N O N O CH 3 O N N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
6-(4-((2,4-dimethylphenyl)sulfonyl)piperazin-1-yl)-N-(pyridin-4-yl)pyridazin-3-amine Depiction based on curated SMILES N N N N H CH 3 N N O O S CH 3 Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
Cyto10C9 Depiction based on curated SMILES Cl Cl N H N CH 3 N N Brucella VirB type IV secretion system Preclinical (in vivo) Paschos A, et al. 2011. Infect Immun
1-(2,4-dimethoxybenzyl)-4-(2,3-dimethylphenyl)piperazine Depiction based on curated SMILES H 3 C O CH 3 H 3 C CH 3 N N O Bacillus Nutritional/Metabolic factor Preclinical (in vitro) Fernandes AS, et al. 2021. Front Microbiol
3-cyclohexyl-1-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one Depiction based on curated SMILES O CH 3 N N O Clostridium TcdB (Toxin B) Preclinical (in vitro) Farrow MA, et al. 2020. ACS Chem Biol
Piperazinehexanamide derivative, 5 Depiction based on curated SMILES N H O CH 3 N N S Coxiella
Legionella		 Dot/Icm T4SS
Dot/Icm (Defect in organella trafficking/intracellular multiplication)		 Preclinical (in vitro)
Preclinical (in vitro)		 Cheng E, et al. 2022. mBio
N-{1-[4-(4-FLUOROPHENYL)PIPERAZIN-1-YL]-1-(THIOPHEN-2-YL)PROPAN-2-YL}-N'-[(PYRIDIN-3-YL)METHYL]ETHANEDIAMIDE Depiction based on curated SMILES HN F HN O O N S N CH 3 N Mycobacterium Exoenzyme Preclinical (in vitro) Chen L, et al. 2010. ACS Med Chem Lett
N-[(FURAN-2-YL)METHYL]-N'-{1-[4-(4-METHOXYPHENYL)PIPERAZIN-1-YL]-1-(THIOPHEN-2-YL)PROPAN-2-YL}ETHANEDIAMIDE Depiction based on curated SMILES O O H 3 C HN O HN O S N CH 3 N Mycobacterium Exoenzyme Preclinical (in vitro) Chen L, et al. 2010. ACS Med Chem Lett
furo[3,2-b]quinoxalin-3-yl-(4-phenylpiperazin-1-yl)methanone Depiction based on curated SMILES N N N O N O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Harmon DE, et al. 2010. Antimicrob Agents Chemother
   


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