Drug details:
Molecular formula: C₂₁H₂₈N₂O₂

Standard name: 1-[(2,4-dimethoxyphenyl)methyl]-4-(2,3-dimethylphenyl)piperazine

Curated SMILES: COC1=CC=C(CN2CCN(C3=CC=CC(C)=C3C)CC2)C(OC)=C1

Evidence for compound's anti-virulence activity:

Bacillus
Related VFcategory: Nutritional/Metabolic factor
Target: KtrAB
Drug effect: Inhibits KtrAB ion channel complex, a component of the K+ homeostasis machinery to interfere with pathogen survival in host cells.
Max phase: Preclinical (in vitro)
Publication:
Fernandes AS, et al., 2021. Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel. Front Microbiol 12:603700.