Drug details:
Molecular formula: C₁₈H₂₀Cl₂N₄

Standard name: 2,5-dichloro-N-[(E)-[2-(4-methylpiperazin-1-yl)phenyl]methylideneamino]aniline

Curated SMILES: CN1CCN(CC1)C2=CC=CC=C2/C=N/NC3=C(C=CC(=C3)Cl)Cl

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.