Drug details:
Molecular formula: C₂₇H₃₇N₃OS

Standard name: 6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide

Synonyms:

6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide 4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide 6-{4-[2-(Methylsulfanyl)phenyl]-1-piperazinyl}-N-(1,2,3,4-tetrahydro-1-naphthalenyl)hexanamide 6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide

Curated SMILES: CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34

Evidence for compound's anti-virulence activity:

Coxiella
Related VF: Dot/Icm T4SS
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.

Legionella
Related VF: Dot/Icm (Defect in organella trafficking/intracellular multiplication)
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.