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1-{4-[(2-nitrophenyl)sulfonyl]piperazin-1-yl}-2-phenoxyethanone

Drug details:
Molecular formula: C18H19N3O6S

Classification: Benzenesulfonamides; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Chemical structure:
Depiction based on curated SMILES S _ O O + N O O O N N O

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Hu X, et al., 2013. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Bioorg Med Chem Lett 23(4):1056-62.








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