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5-{3-bromo-4-[(4-nitrobenzyl)oxy]benzylidene}pyrimidine-2,4,6(1H,3H,5H)-trione

Drug details:
Molecular formula: C18H12BrN3O6

Classification: Pyrimidines and pyrimidine derivatives; Diazines; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES _ O O + N Br O HN O NH O O

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Hu X, et al., 2013. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Bioorg Med Chem Lett 23(4):1056-62.








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