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5-({(E)-[2-(4-chlorophenyl)-5-oxo-1,3-oxazol-4(5H)-ylidene]methyl}amino)-2-hydroxybenzoic acid

Drug details:
Molecular formula: C17H11ClN2O5

Classification: Benzoic acids and derivatives; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Chemical structure:
Depiction based on curated SMILES HO O O Cl O N N H HO

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Hu X, et al., 2013. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Bioorg Med Chem Lett 23(4):1056-62.








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