Drug details:
Molecular formula: C₁₁H₉N₅O₂S

Standard name: 1,6-dimethyl-3-thiophen-2-ylpyrimido[5,4-e][1,2,4]triazine-5,7-dione

Synonym:

1,6-Dimethyl-3-(2-thienyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione

Curated SMILES: CN1C2=NC(=O)N(C(=O)C2=NC(=N1)C3=CC=CS3)C

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Hu X, et al., 2013. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Bioorg Med Chem Lett 23(4):1056-62.