Drug details:
Molecular formula: C₁₃H₁₀ClN₅O₂

Standard name: 3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione

Synonyms:

3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione 3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione 3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione 3-(4-chlorophenyl)-1,6-e][1,2,4]triazine-5,7-dione 1,6-Dimethyl-3-(4-chlorophenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione 1H-Pyrimido[5,4-E][1,2,4]triazine-5,7-dione, 3-(4-chlorophenyl)-1,6-dimethyl- 3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone Pyrimido(5,4-e)-1,2,4-triazine-5,7-(1H,6H)-dione, 3-(4-chlorophenyl)-1,6-dimethyl-

Curated SMILES: CN1N=C(C2=CC=C(Cl)C=C2)N=C2C(=O)N(C)C(=O)N=C21

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Hu X, et al., 2013. Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Bioorg Med Chem Lett 23(4):1056-62.