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2-chloro-4-{5-[(E)-2-(4,6-dihydroxy-5-nitropyrimidin-2-yl)ethenyl]furan-2-yl}benzoic acid

Drug details:
Molecular formula: C17H10ClN3O7

Classification: Benzoic acids and derivatives; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Synonym:  2-chloro-4-{5-[(E)-2-(4-hydroxy-5-nitro-6-oxo-1,6-dihydropyrimidin-2-yl)ethenyl]furan-2-yl}benzoic acid

Chemical structure:
Depiction based on curated SMILES O NH O _ O O + N HO N O Cl OH

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Protein tyrosine phatase YopH inhibitor.
Max phase: Preclinical (in vitro)
Publication:
Eriksson J, et al., 2012. Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis. Adv Exp Med Biol 954:357-63.








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