Drug details:
Molecular formula: C₁₈H₁₂O₂

Standard name: 2-pyren-1-ylacetic acid

Synonyms:

2-pyren-1-ylacetic acid 1-Pyreneaceticacid 2-(pyren-1-yl)acetic acid 3-Pyrenylacetic acid Pyrene-1-acetic acid 1-pyreneacetic 1-Pytrneacetic acid 1-pyrene acetic acid 1-Pyrenylacetic acid # ......

Curated SMILES: C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CC(=O)O

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vivo)
Publication:
Liang F, et al., 2003. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278(43):41734-41.