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(S)-(-)-Indoline-2-carboxylic acid

Drug details:
Molecular formula: C9H9NO2

Classification: Indolecarboxylic acids and derivatives; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;
Synonyms:  (S)-Indoline-2-carboxylic acid
(2S)-2,3-dihydro-1H-indole-2-carboxylic acid
(s)-2,3-dihydro-1h-indole-2-carboxylic acid
(S)-(-)-Indolin-2-carboxylic acid
L-Indoline-2-carboxylic acid
s-(-)-indoline-2-carboxylic acid
1H-Indole-2-carboxylic acid, 2,3-dihydro-, (2S)-
h-idc-oh
Indoline-2-carboxylic acid, (S)-
......

Curated SMILES: C1C(NC2=CC=CC=C21)C(=O)O
Chemical structure:
Depiction based on curated SMILES N H O OH

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vivo)
Publication:
Liang F, et al., 2003. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278(43):41734-41.








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