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3,7-Dihydroxy-2-naphthoic acid

Drug details:
Molecular formula: C11H8O4

Classification: Naphthalenecarboxylic acids and derivatives; Naphthalenes; Benzenoids; Organic compounds;
Synonyms:  3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID
2,6-Dihydroxy-3-Naphthoic acid
3,7-dihydroxy-2-naphtoic acid
3,7-Dihydroxy-2-naphthoic acid, 95%

Chemical structure:
Depiction based on curated SMILES OH O OH HO

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vivo)
Publication:
Liang F, et al., 2003. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278(43):41734-41.








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