Drug details:
Molecular formula: C₁₇H₁₀O₂

Standard name: pyrene-1-carboxylic acid

Synonyms:

pyrene-1-carboxylic acid 1-Pyrenecarboxylicacid 1-Pyrenecarboxylic acid, 97%

Curated SMILES: O=C(O)C1=C2C=CC3=CC=CC4=CC=C(C=C1)C2=C34

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vivo)
Publication:
Liang F, et al., 2003. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278(43):41734-41.