Drug details:
Molecular formula: C₂₀H₁₆O₂

Standard name: 2,2,2-triphenylacetic acid

Synonyms:

2,2,2-triphenylacetic acid Acetic acid, triphenyl- Benzeneacetic acid, .alpha.,.alpha.-diphenyl- EINECS 209-873-4 alpha-Toluic acid, alpha,alpha-diphenyl- Benzeneacetic acid, alpha,alpha-diphenyl- triphenyl acetic acid Tritylformic acid tri phenylacetic acid ......

Curated SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)O

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vivo)
Publication:
Liang F, et al., 2003. Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem 278(43):41734-41.