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5-[5-(2,3-Dihydro-6,7-dimethyl-3-oxothiazolo[3,2-a]benzimidazole-2-ylidenemethyl)-2-furanyl]-2-hydroxybenzoic acid

Drug details:
Molecular formula: C23H16N2O5S

Classification: Benzoic acids and derivatives; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Synonym:  5-{5-[(6,7-dimethyl-3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]-2-furyl}-2-hydroxybenzoic acid

Chemical structure:
Depiction based on curated SMILES N S HO O OH O CH 3 O N CH 3

Evidence for compound's anti-virulence activity:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: Preclinical (in vitro)
Publication:
Tautz L, et al., 2005. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem 280(10):9400-8.








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