Drug details:
Molecular formula: C₁₆H₁₂BrN₃O₃S₂

Standard name: 4-[(5-bromo-2-hydroxyphenyl)methylideneamino]-N-(1,3-thiazol-2-yl)benzenesulfonamide

Synonyms:

4-((5-BROMO-2-HYDROXYBENZYLIDENE)AMINO)-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE 4-([(E)-(5-Bromo-2-hydroxyphenyl)methylidene]amino)-N-(1,3-thiazol-2-yl)benzenesulfonamide #

Curated SMILES: O=S(=O)(NC1=NC=CS1)C1=CC=C(/N=C/C2=CC(Br)=CC=C2O)C=C1

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Having a significant and dramatic effect on the expression of Ler-dependent genes that encode virulence factors within (EspB, Tir, type III apparatus) and outside (EspC) the LEE.
Max phase: Preclinical (in vitro)
Publication:
Gauthier A, et al., 2005. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob Agents Chemother 49(10):4101-9.