Drug details:
Molecular formula: C₁₃H₁₅Cl₂N₃O₂S

Standard name: N-[[(E)-(3,5-dichloro-2-hydroxyphenyl)methylideneamino]carbamothioyl]-2,2-dimethylpropanamide

Curated SMILES: CC(C)(C)C(=O)NC(=S)N/N=C/C1=C(C(=CC(=C1)Cl)Cl)O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Having a significant and dramatic effect on the expression of Ler-dependent genes that encode virulence factors within (EspB, Tir, type III apparatus) and outside (EspC) the LEE.
Max phase: Preclinical (in vitro)
Publication:
Gauthier A, et al., 2005. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob Agents Chemother 49(10):4101-9.