Drug details:
Molecular formula: C₂₉H₂₃NO₃S

Standard name: 2-benzyl-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxo-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid

Curated SMILES: O=C(O)C1=C(CC2=CC=CC=C2)SC2=C(C3CC3)C(CC3=CC=CC4=C3C=CC=C4)=CC(=O)N21

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: Type 1 fimbriae; P fimbriae; S fimbriae
Target: Not determined
Drug effect: Disrupt the production of type 1, P and S pili, as well as flagella through alteral regulation and assembly of these VFs.
Max phase: Preclinical (in vivo)
Publication:
Greene SE, et al., 2014. Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli. mBio 5(6):e02038.