Drug details:
Molecular formula: C₁₂H₁₇NO₃

Standard name: N,N-diethyl-4-hydroxy-3-methoxybenzamide

Synonyms:

Vanillic acid diethylamide Emivan Vandid Analepticon Etamivanum Simaron N,N-Diethylvanillamide Cardiovanil Corivanil ......

Curated SMILES: CCN(CC)C(=O)C1=CC(=C(C=C1)O)OC

Evidence for compound's anti-virulence activity:

Coxiella
Related VF: Dot/Icm T4SS
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.

Legionella
Related VF: Dot/Icm (Defect in organella trafficking/intracellular multiplication)
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.