Drug details:
Molecular formula: C₂₁H₂₆ClN₃OS

Standard name: 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol

Synonyms:

Trilafon Perphenazin Perfenazine Etaperazine Ethaperazine Etaperazin Fentazin Chlorpiprazine Decentan ......

Curated SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

Evidence for compound's anti-virulence activity:

Coxiella
Related VF: Dot/Icm T4SS
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.

Legionella
Related VF: Dot/Icm (Defect in organella trafficking/intracellular multiplication)
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.