Drug details:
Molecular formula: C₂₃H₂₆N₂O

Standard name: 3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol

Synonyms:

Roxindole [INN] 3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-1H-indol-5-ol 3-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)-1H-indol-5-ol 3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indol-5-ol roxindol 3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridylbutyl)indol-5-ol 3-(4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl)-1H-indol-5-ol roxindolum ROXINDOLE [MI]

Curated SMILES: C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O

Evidence for compound's anti-virulence activity:

Coxiella
Related VF: Dot/Icm T4SS
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.

Legionella
Related VF: Dot/Icm (Defect in organella trafficking/intracellular multiplication)
Target: Not determined
Drug effect: Interferes with cargo delivery by the T4SS.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.