Drug details:
Molecular formula: C₂₀H₂₃N

Standard name: N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine

Synonyms:

Maprotylina [Polish] Maprotylina Maprotilinum [INN-Latin] Maprotilina [INN-Spanish] 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl- 276-Ba N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine Maprotiline (USAN) 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)propylmethylamine ......

Curated SMILES: CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24

Evidence for compound's anti-virulence activity:

Francisella
Related VFcategory: Regulation
Target: QseC
Drug effect: Decreases biofilm formation in vitro by disrupting QseC-dependent tow-component system signaling.
Max phase: Preclinical (in vivo)
Publication:
Dean SN, et al., 2015. Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity in Francisella novicida. Virulence 6(5):487-503.