Drug details:
Molecular formula: C₁₃H₈N₄O₃

Standard name: (3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile

Synonyms:

2-Amino-1,1,3-tricyano-4-(3',4',5'-trihydroxyphenyl)butadiene (3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)- (Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile 3-Amino-2,4-dicyano-5-(3',4',5'-trihydroxyphenyl)penta-2,4-dienonitrile 2-Amino-1,1,3-tricyano-4-[3',4',5'-trihydroxyphenyl]butadiene Tyrphostin 51, >=98% 2-amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-

Curated SMILES: C1=C(C=C(C(=C1O)O)O)C=C(C#N)C(=C(C#N)C#N)N

Evidence for compound's anti-virulence activity:

Francisella
Related VF: Acid phosphatase
Target: AcpA
Drug effect: Inhibits a secreted alkaline phosphatase AcpA activity to reduce intracellular burden of F. tularensis.
Max phase: Preclinical (in vitro)
Publication:
Fernández-Soto P, et al., 2021. Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis. Sci Rep 11(1):7667.

Mycobacterium
Related VFcategory: Exoenzyme
Target: SapM
Drug effect: Inhibits a secreted alkaline phosphatase SapM activity to reduce intracellular mycobacterial survival in host macrophages.
Max phase: Preclinical (in vitro)
Publication:
Fernández-Soto P, et al., 2021. Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis. Sci Rep 11(1):7667.