Drug details:
Molecular formula: C₁₅H₁₀O₈

Standard name: 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one

Synonyms:

Cannabiscetin Myricetol Myricitin 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one 3,3',4',5,5',7-Hexahydroxyflavone 3,5,7,3',4',5'-Hexahydroxyflavone 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)- ......

Curated SMILES: C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

Evidence for compound's anti-virulence activity:

Helicobacter
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Has the ability to slow down the process of transformation into coccoid forms and reduces biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Krzyzek P, et al., 2021. Myricetin as an Antivirulence Compound Interfering with a Morphological Transformation into Coccoid Forms and Potentiating Activity of Antibiotics against Helicobacter pylori. Int J Mol Sci 22(5):2695.

Listeria
Related VF: LLO (Listeriolysin O)
Target: Hly
Drug effect: Inhibits the activity of LLO.
Max phase: Preclinical (in vitro)
Publication:
Wang J, et al., 2015. Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling. Sci Rep 5:8864.

Staphylococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Hu P, et al., 2021. Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation. Int J Med Microbiol 311(4):151512.