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Thioridazine

Drug details:
Molecular formula: C21H26N2S2

Classification: Phenothiazines; Benzothiazines; Organoheterocyclic compounds; Organic compounds;
Synonyms:  Mellaril
Thioridazin
Mellerette
Melleril
Sonapax
Mellaril-S
Malloryl
Meleril
Mellerets
......

Chemical structure:
Depiction based on curated SMILES CH 3 S S H 3 C N N

Evidence for compound's anti-virulence activity:

Neisseria
Related VF: Type IV pili
Target: Not determined
Drug effect: Blocks functions associated with Type IV pili by affecting piliation within minutes.
Max phase: Preclinical (in vivo)
Publication:
Denis K, et al., 2019. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol 4(6):972-984.








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