Drug details:
Molecular formula: C₁₅H₁₀O₅

Standard name: 5,6,7-trihydroxy-2-phenylchromen-4-one

Synonyms:

5,6,7-Trihydroxyflavone Noroxylin 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one Biacalein BaiKalein 5,6,7-trihydroxy-2-phenylchromen-4-one 5,6,7-trihydroxy-2-phenyl-chromen-4-one 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one 5,7-Trihydroxyflavone ......

Curated SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O

Evidence for compound's anti-virulence activity:

Listeria
Related VF: LLO (Listeriolysin O)
Target: Hly
Drug effect: Inhibits bacterial colonization and multiplication by targeting SrtA and LLO.
Max phase: Preclinical (in vivo)
Publications:
Wang J, et al., 2015. Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling. Sci Rep 5:8864.
Lu G, et al., 2019. A potential bio-control agent from baical skullcap root against listeriosis via the inhibition of sortase A and listeriolysin O. J Cell Mol Med 23(3):2042-2051.