VFDB - anti-virulence compound Heptanoic acid [4-(2-amino-3H-imidazol-4-yl)phenyl]amide hydrochloride

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

Heptanoic acid [4-(2-amino-3H-imidazol-4-yl)phenyl]amide hydrochloride

Drug details:
Molecular formula: C₁₆H₂₃ClN₄O

Standard name: N-[4-(2-amino-1H-imidazol-5-yl)phenyl]heptanamide;hydrochloride

Classification: Imidazoles; Azoles; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: CCCCCCC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)N.Cl

Chemical structure:

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Bunders CA, et al., 2010. Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria. Bioorg Med Chem Lett 20(12):3797-800.


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