Drug details:
Molecular formula: C₁₈H₂₁N₅S

Standard name: 4-N-(2-methylpropyl)-2-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine

Synonyms:

N4-(2-Methylpropyl)-N2-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine 4-N-(2-methylpropyl)-2-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine KHS-101? 2,4-Pyrimidinediamine, N4-(2-methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]- KHS101, >=98% (HPLC)

Curated SMILES: CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3

Evidence for compound's anti-virulence activity:

Legionella
Related VF: Dot/Icm (Defect in organella trafficking/intracellular multiplication)
Target: Not determined
Drug effect: T4SS inhibitor and growth inhibitory activity limited to L. pneumophila.
Max phase: Preclinical (in vitro)
Publication:
Cheng E, et al., 2022. A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System. mBio 13(2):e0024022.