Drug details:
Molecular formula: C₂₃H₂₁N₃O

Standard name: (3S)-3-amino-4-(1H-imidazol-5-yl)-1-(4-naphthalen-2-ylphenyl)butan-2-one

Curated SMILES: C1=CC=C2C=C(C=CC2=C1)C3=CC=C(C=C3)CC(=O)[C@H](CC4=CN=CN4)N

Evidence for compound's anti-virulence activity:

Brucella
Related VFcategory: Others
Target: Histidinol dehydrogenase (HDH)
Drug effect: Inhibits HDH activity to interfere with histidine biosynthesis which is essential for intramacrophagic replication.
Max phase: Preclinical (in vitro)
Publication:
Abdo MR, et al., 2011. Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors. Org Biomol Chem 9(10):3681-90.