Drug details:
Molecular formula: C₂₅H₂₇N₃O

Standard name: (3S)-3-amino-1-[4-[2-(4-tert-butylphenyl)ethynyl]phenyl]-4-(1H-imidazol-5-yl)butan-2-one

Curated SMILES: CC(C)(C)C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CC(=O)[C@H](CC3=CN=CN3)N

Evidence for compound's anti-virulence activity:

Brucella
Related VFcategory: Others
Target: Histidinol dehydrogenase (HDH)
Drug effect: Inhibits HDH activity to interfere with histidine biosynthesis which is essential for intramacrophagic replication.
Max phase: Preclinical (in vitro)
Publication:
Abdo MR, et al., 2011. Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors. Org Biomol Chem 9(10):3681-90.