Drug details:
Molecular formula: C₁₈H₁₃N₃O₅

Standard name: 2-hydroxy-N-[(Z)-[5-(2-nitrophenyl)furan-2-yl]methylideneamino]benzamide

Curated SMILES: O=C(N/N=C/C1=CC=C(C2=C([N+](=O)[O-])C=CC=C2)O1)C1=C(O)C=CC=C1

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publications:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.
Smith MA, et al., 2012. Identification of the binding site of Brucella VirB8 interaction inhibitors. Chem Biol 19(8):1041-8.