Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication: Smith MA, et al., 2012. Identification of the binding site of Brucella VirB8 interaction inhibitors. Chem Biol 19(8):1041-8.