Drug details:
Molecular formula: C₈H₆Cl₂N₂O₆P₂

Standard name: (6,7-dichloro-3-phosphonoquinoxalin-2-yl)phosphonic acid

Curated SMILES: C1=C2C(=CC(=C1Cl)Cl)N=C(C(=N2)P(=O)(O)O)P(=O)(O)O

Evidence for compound's anti-virulence activity:

Bacillus
Related VF: Collagenase
Target: ColQ1;ColA
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.

Clostridium
Related VF: Collagenase
Target: ColG;ColH
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.