Drug details:
Molecular formula: C₂₃H₃₂N₂

Standard name: N-benzyl-N-(2-phenylethyl)-1-propylpiperidin-4-amine

Curated SMILES: CCCN1CCC(N(CCC2=CC=CC=C2)CC2=CC=CC=C2)CC1

Evidence for compound's anti-virulence activity:

Bacillus
Related VFcategory: Nutritional/Metabolic factor
Target: KtrAB
Drug effect: Inhibits KtrAB ion channel complex, a component of the K+ homeostasis machinery to interfere with pathogen survival in host cells.
Max phase: Preclinical (in vitro)
Publication:
Fernandes AS, et al., 2021. Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel. Front Microbiol 12:603700.