Drug details:
Molecular formula: C₁₆H₁₇BrFNO

Standard name: N-[(5-bromo-2-methoxyphenyl)methyl]-2-(3-fluorophenyl)ethanamine

Synonyms:

N-(5-bromo-2-methoxybenzyl)-2-(3-fluorophenyl)ethanamine N-[(5-bromo-2-methoxyphenyl)methyl]-2-(3-fluorophenyl)ethanamine N-(5-BROMO-2-METHOXYBENZYL)-N-(3-FLUOROPHENETHYL)AMINE [(5-BROMO-2-METHOXYPHENYL)METHYL][2-(3-FLUOROPHENYL)ETHYL]AMINE N-[(5-Bromo-2-methoxyphenyl)methyl]-2-(3-fluorophenyl)ethan-1-amine

Curated SMILES: COC1=C(C=C(C=C1)Br)CNCCC2=CC(=CC=C2)F

Evidence for compound's anti-virulence activity:

Bacillus
Related VFcategory: Nutritional/Metabolic factor
Target: KtrAB
Drug effect: Inhibits KtrAB ion channel complex, a component of the K+ homeostasis machinery to interfere with pathogen survival in host cells.
Max phase: Preclinical (in vitro)
Publication:
Fernandes AS, et al., 2021. Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel. Front Microbiol 12:603700.