Drug details:
Molecular formula: C₂₇H₂₉N₃O

Standard name: 1-hydroxy-3-[(4-methylphenyl)-(4-methylpiperazin-1-yl)methyl]-2-phenylindole

Curated SMILES: CC1=CC=C(C(C2=C(C3=CC=CC=C3)N(O)C3=C2C=CC=C3)N2CCN(C)CC2)C=C1

Evidence for compound's anti-virulence activity:

Burkholderia
Related VF: Quorum-sensing
Target: BmaI1
Drug effect: Inhibits acyl-HSL synthase BmaI1 activity.
Max phase: Preclinical (in vitro)
Publication:
Christensen QH, et al., 2013. A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases. Proc Natl Acad Sci U S A 110(34):13815-20.