Drug details:
Molecular formula: C₁₁H₉NO₂

Standard name: (E)-3-(1H-indol-3-yl)prop-2-enoic acid

Synonyms:

trans-3-Indoleacrylic acid INDOLE-3-ACRYLIC ACID 3-(1H-Indol-3-yl)acrylic acid Indoleacrylic acid 3-Indolylacrylic acid trans-Indole-3-acrylic acid (E)-3-(1H-indol-3-yl)prop-2-enoic acid Indole-3beta-acrylic acid 2-Propenoic acid, 3-(1H-indol-3-yl)-, (2E)- ......

Curated SMILES: C1=CC=C2C(=C1)C(=CN2)/C=C/C(=O)O

Evidence for compound's anti-virulence activity:

Burkholderia
Related VF: Quorum-sensing
Target: BmaI1
Drug effect: Inhibits acyl-HSL synthase BmaI1 activity.
Max phase: Preclinical (in vitro)
Publication:
Christensen QH, et al., 2013. A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases. Proc Natl Acad Sci U S A 110(34):13815-20.