Drug details:
Molecular formula: C₁₇H₁₀ClF₃N₂O

Standard name: (4Z)-4-[(4-chlorophenyl)methylidene]-2-phenyl-5-(trifluoromethyl)pyrazol-3-one

Curated SMILES: C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(C=C3)Cl)/C(=N2)C(F)(F)F

Evidence for compound's anti-virulence activity:

Haemophilus
Related VF: LOS
Target: LgtC
Drug effect: Inhibits α-1,4-galactosyltransferase LgtC.
Max phase: Preclinical (in vitro)
Publication:
Xu Y, et al., 2018. Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC. Bioorg Med Chem 26(11):2973-2983.