Drug details:
Molecular formula: C₁₉H₁₂BrF₃N₂O₄

Standard name: 4-[(4Z)-4-[(3-bromo-4-methoxyphenyl)methylidene]-5-oxo-3-(trifluoromethyl)pyrazol-1-yl]benzoic acid

Curated SMILES: COC1=C(C=C(C=C1)/C=C\2/C(=NN(C2=O)C3=CC=C(C=C3)C(=O)O)C(F)(F)F)Br

Evidence for compound's anti-virulence activity:

Haemophilus
Related VF: LOS
Target: LgtC
Drug effect: Inhibits α-1,4-galactosyltransferase LgtC.
Max phase: Preclinical (in vitro)
Publication:
Xu Y, et al., 2018. Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC. Bioorg Med Chem 26(11):2973-2983.