Drug details:
Classification: Trifluoromethylbenzenes; Benzene and substituted derivatives; Benzenoids; Organic compounds;

Curated SMILES: FC(F)(F)C1=CC=C(CNC2=NC=CC(C3=CNC4=CC=C(Br)C=C43)=N2)C=C1

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm and/or acts as adjuvants to overcome resistance to colistin.
Max phase: Preclinical (in vitro)
Publication:
Zeiler MJ, et al., 2020. Second-Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin. ChemMedChem 15(17):1672-1679.