Drug details:
Molecular formula: C₂₁H₁₈O₃

Standard name: (E)-1-(2,5-dimethoxyphenyl)-3-naphthalen-1-ylprop-2-en-1-one

Synonyms:

(E)-1-(2,5-dimethoxyphenyl)-3-(1-naphthyl)prop-2-en-1-one 1-(2'',5''-dimethoxyphenyl)-3-(1-naphthyl)-2-propen-1-one (2e)-1-(2,5-dimethoxyphenyl)-3-(1-naphthyl)-2-propen-1-one (2E)-1-(2,5-Dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one (2E)-1-(2'',5''-dimethoxyphenyl)-3-(1-naphthyl)-2-propen-1-one

Curated SMILES: COC1=CC(=C(C=C1)OC)C(=O)/C=C/C2=CC=CC3=CC=CC=C32

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpA
Drug effect: Inhibits protein tyrosine phosphatase PtpA to disrupt phagosome acidification and maturation.
Max phase: Preclinical (in vitro)
Publications:
Chiaradia LD, et al., 2008. Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett 18(23):6227-30.
Mascarello A, et al., 2010. Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth. Bioorg Med Chem 18(11):3783-9.